Dysregulation of lipid metabolism in Tangier monocyte-derived macrophages.

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Dysregulation of lipid metabolism in Tangier monocyte-derived macrophages.

The cellular defect in Tangier mononuclear phagocytes (MNP) was shown to be associated with significant abnormalities in cellular phospholipid, triglyceride, and cholesteryl ester metabolism by using various radiolabeled precursors (32Pi, 3H-serine, 3H-choline, 14C-acetate, and 14C-oleic acid). Tangier MNP expressed increased rates of synthesis for phospholipids (twofold), triglycerides (fivefo...

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ژورنال

عنوان ژورنال: Arteriosclerosis: An Official Journal of the American Heart Association, Inc.

سال: 1990

ISSN: 0276-5047

DOI: 10.1161/01.atv.10.6.1010